Pathology findings :
The tumour is
non-encapsulated, moderately circumscribed, and extends
through the whole dermis.
It is composed of
spindle and stellate cells with slight nuclear atypia arranged in
a loose storiform, partly fascicular growth pattern.
Occasional
multinucleated stromal cells are present.
The neoplastic
cells are embedded in a myxoid stroma.
There is an
increased numbers of small blood vessels.
A few mast cells
are noted. There are occasional mitotic figures.
Differential diagnosis:
Includes benign
and malignant myxoid and spindle cells tumours such as:
Fibrous Histiocytoma ;
Dermatofibrosarcoma Protuberans
;
Acquired (digital)
fibrokeratoma ;
Myxoid
neurofibroma;
Neurofibroma and variants
Sclerosing
Perineurioma
;
Cutaneous myxoma (superficial
angiomyxoma),and
Acral
myxoinflammatory fibroblastic sarcoma.
Immunohistochemical finding:
The tumour cells
may show focal positivity with CD34, EMA and CD99 may be positive
in some and negative in others.
The tumour is
usually negative for S-100 protein, HMB45 and alpha-smooth muscle
actin and cytokeratin.
Alcian blue
staining reveals abundant mucinous material within the stroma.
Recurrence rate of
this tumor may be more than 20%. |