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Pathology of Argentine Hemorrhagic Fever (caused by Junin Virus)

Dr Sampurna Roy MD     

 

Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement.

(Arenaviruses include Junin virus, Lassa virus, Machupo virus, Guanarito virus and Sabia).  

Visit: Lassa Fever

It is a severe illness whose symptoms resemble those of Korean Hemorrhagic Fever .

An epidemic developed in rural agricultural areas and villages northwest of Buenos Aires in 1958.

The virus is found naturally in wild rodents and may be transmitted in food or contaminated airborne dust.

The incubation period is usually from 6 to 14 days. Most infections with Junin virus (80%) result in clinical disease. Three phases are recognized in the illness: prodromal, neurological–hemorrhagic, and convalescence.

AHF are believed to result from inhalation of virus-containing material from infected rodents. Viral replication is thought to occur at the initial site of infection, generally the lungs, with subsequent dissemination to other parenchymal tissues.

A wide variety of organs may be affected, including vascular endothelium, myocardium, kidneys and the central nervous system.

The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia.

Hemorrhagic Fever Viruses as Biological Weapons (full article-JAMA)

 

Related posts: 

Crimean-Congo Hemorrhagic Fever ;   

Marburg Virus Disease ;

Lymphocytic choriomeningitis ;  Omsk hemorrhagic fever ;

Rift Valley Fever. 

 

Further reading:

Viral Hemorrhagic Fevers | CDC Special Pathogens Branch

Arenaviruses | CDC Special Pathogens Branch

Argentinian hemorrhagic fever: essential data

Antiviral treatment of Argentine hemorrhagic fever.

Argentine Hemorrhagic Fever — Alterations of the Complement System and Anti-Junin-Virus Humoral Response

A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever.

Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever

                                                                                                                      

 

 

Visit:-  Dermatopathology Online

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


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