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Dermpath-India Pathology of Pigmented Spindle Cell Nevus (Reed Nevus) Dr Sampurna Roy MD 2022
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Reed nevus or pigmented spindle-cell nevus was first described by Reed in 1975. Pigmented spindle cell nevus is regarded as a distinct entity and not part of spindle cell variant of Spitz nevus. Clinically, these lesions present as symmetrical, sharply circumscribed, darkly pigmented nodule or papule (usually less than 0.6 cm in diameter). These lesions occur most commonly on the extremities and back with a predilection for the legs. These are more common in women in the third decade of life.
Differential diagnosis include melanoma. Pigmented spindle cell nevus that can show worrisome clinical and histologic features mimicking a malignant melanoma. Unlike melanoma these are symmetrical lesions and display maturation of cells in the deeper part of the lesion. Pagetoid spread of cells is limited to the lower half of the epidermis. Clinical and histologic assessment is essential in establishing the diagnosis. Ancillary techniques such as proliferation antigen Ki-67, cyclin D1, survivin, and FISH can be useful as adjunctive tools. Dermatopathology Quiz Case 135 [Pathology Infographic] Raining down appearance of Pigmented Spindle Cell Nevus (Reed Nevus)
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