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Dermpath-India Pathology of Primary Cutaneous Adenoid Cystic Carcinoma Dr Sampurna Roy MD 2023
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This is a rare form of sweat gland carcinoma which has a striking resemblance to the adenoid cystic carcinoma of the salivary glands. It was first described by Boggio in the 1975. Adenoid cystic carcinomas are regarded by some authors as apocrine in origin. This tumour affects middle-aged and older individuals (mean age 59) and has predilection for women. It is characterized by indolent course and local aggressive behaviour. Site: This tumour is most common in the scalp. It may be located on the chest and abdomen. Rarely the tumour arises from the skin of the eyelid. If the scalp is involved, alopecia is generally an associated finding.
Differential diagnoses: 1. Adenoid basal cell carcinoma: [Adenoid cystic carcinoma is characterized by: Absence of retraction artefact , absence of contiguity with the epidermis or hair sheaths ,lack of peripheral palisading of the nuclei, and occasional presence of central apoptotic or even necrotic cells. Pseudocysts stain positively to Alcian blue and periodic acid-Schiff ]. 2. Primary cutaneous cribriform carcinoma: Primary cutaneous cribriform carcinoma: a rare apocrine tumour. Unlike most of the sweat gland carcinomas, this tumour tends to recur locally and rarely spreads to lymph nodes or distant organs.
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Further reading:
Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases
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Prof (Dr) Haradhan Roy MD (AIIMS) (1928-2022) (R) Director-Professor and Head of the Dept of Pathology, Calcutta National Medical College, Calcutta University India |
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